Symposium Session: Role of Dietary Phytochemicals in Human Health and Disease Prevention
This is not a webinar or course for purchase- this is a module for credit claiming for our 2019 Spring Symposium attendees and cannot be purchased or taken by non-attendees. These sessions are exclusive to our symposium, however, the topics may be revisited in the future in the form of a webinar or self-study course.
Suggested CDR Learning Codes: 2010, 4040
Performance Indicators: 8.1.4, 8.1.5, 8.3.6
Phytochemicals (“phytonutrients”) play an important role in human health promotion and disease prevention, and increasing evidence supports the beneficial effects of polyphenols (a ubiquitous class of phytochemicals abundant in colorful fruit and vegetables and their derived products) against several chronic human illnesses including CVD, obesity, metabolic syndrome, certain cancers, and neurodegenerative diseases. However, given that polyphenols have low/poor bioavailability and undergo extensive hepatic metabolism, whether they are present in circulation in their intact/parent forms in physiologically relevant levels is questionable. Emerging data support the role of the human gut microbiota in the conversion of polyphenols into bioactive gut microbial metabolites, which may contribute to the health benefits of polyphenol-rich foods. This presentation will highlight research on pomegranate polyphenols (known as ellagitannins) and their bioactive gut microbial metabolites (known as urolithins) and how interindividual variability in gut microbiota composition leads to “responders” and “nonresponders” among human subjects.
After attending this session, nutrition professionals should be able to:
- Gain knowledge of plant-derived drugs and phytomedicines.
- Gain knowledge of dietary polyphenols and how their bioavailability, metabolism, and tissue disposition influence their biological effects.
- Understand the role of colonic microflora in the conversion of polyphenols into polyphenol microbial metabolites (PMMs) and the gut-brain axis.
- Understand the role of PMMs on aging and neurodegenerative diseases including Alzheimer’s disease.
Navindra Seeram, PhD, is a professor in the College of Pharmacy at The University of Rhode Island. Prior to this, he was the assistant director of the UCLA Center for Human Nutrition in the Department of Medicine, UCLA. His research group, the Bioactive Botanical Research Laboratory, investigates medicinal plant foods for preventive and therapeutic effects against chronic human diseases. Navindra has coauthored over 170 original peer-reviewed research articles, 10 review-type articles, 17 book chapters, six international patents, and has coedited three books.
Navindra Seeram, PhD, reports the following relevant disclosures: Received grant/research support from the Maple Syrup Federation of Quebec; Consultant for Amazentis, SA. He has certified that no conflict of interest exists for this program. View our disclosure policy.
- 1.00 CDR